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A manipulação magistral, por outro lado, é regulamentada por normativas específicas — em particular a RDC nº 67 de 2007 e a RDC nº 7 de 2015 — voltadas a preparações individualizadas, com requisitos de boas práticas, mas sem a mesma exigência de evidência clínica robusta para cada uso

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Comparing oral and intramuscular vitamin B12, a 2005 Cochrane Review revised in 2018 revealed that large doses of oral vitamin B12 might be equally effective as intramuscular delivery in achieving short-term hematological and neurological responses in vitamin B12-deficient individuals